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Issue 3, 2014
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Improved synthesis of tadalafil using dimethyl carbonate and ionic liquids

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Abstract

An improved synthesis of tadalafil, a drug for the treatment of male erectile dysfunction, involves the use of safer solvents and reagents as well as a reduced number of steps.

Graphical abstract: Improved synthesis of tadalafil using dimethyl carbonate and ionic liquids

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Publication details

The article was received on 21 Oct 2013, accepted on 14 Nov 2013 and first published on 15 Nov 2013


Article type: Paper
DOI: 10.1039/C3RA45982A
RSC Adv., 2014,4, 1204-1211

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    Improved synthesis of tadalafil using dimethyl carbonate and ionic liquids

    M. J. Earle, M. Noè, A. Perosa and K. R. Seddon, RSC Adv., 2014, 4, 1204
    DOI: 10.1039/C3RA45982A

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