Jump to main content
Jump to site search

Issue 28, 2014
Previous Article Next Article

Enantioselective synthesis of pyrazolone derivatives catalysed by a chiral squaramide catalyst

Author affiliations

Abstract

An efficient chiral squaramide-catalysed enantioselective Michael addition of pyrazolin-5-ones to β,γ-unsaturated α-ketoesters has been developed. The chiral pyrazolone derivatives were obtained in moderate to high yields (up to 99% yield) with high enantioselectivities (up to 96% ee) for most substrates. This catalytic asymmetric reaction provides valuable and easy access to chiral pyrazolone ketoester derivatives.

Graphical abstract: Enantioselective synthesis of pyrazolone derivatives catalysed by a chiral squaramide catalyst

Back to tab navigation

Supplementary files

Article information


Submitted
21 Oct 2013
Accepted
10 Mar 2014
First published
11 Mar 2014

RSC Adv., 2014,4, 14538-14545
Article type
Paper

Enantioselective synthesis of pyrazolone derivatives catalysed by a chiral squaramide catalyst

J. Li and D. Du, RSC Adv., 2014, 4, 14538
DOI: 10.1039/C3RA45974H

Social activity

Search articles by author

Spotlight

Advertisements