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Issue 12, 2014
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Synthesis and toxicity testing of cysteine-functionalized single-walled carbon nanotubes with Caenorhabditis elegans

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Abstract

As carbon nanotubes are incorporated into commercial products in ever-increasing amounts, it is important to produce nontoxic nanotubes and have a reliable method for testing their toxicity. This article reports the synthesis and characterization of cysteine-functionalized single-walled carbon nanotubes and the usefulness of toxicity tests employing the nematode Caenorhabditis elegans. The cysteine-functionalized nanotubes have good aqueous solubility and are nontoxic to C. elegans. Additionally, the cysteine-functionalized nanotubes are shown to be capable of delivering a pharmaceutical compound through a cleavable disulfide bond. This work presents a straightforward synthesis of an easily synthesized, biocompatible carbon nanotube that will have applications in biomedicine.

Graphical abstract: Synthesis and toxicity testing of cysteine-functionalized single-walled carbon nanotubes with Caenorhabditis elegans

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Supplementary files

Article information


Submitted
04 Sep 2013
Accepted
18 Dec 2013
First published
09 Jan 2014

RSC Adv., 2014,4, 5893-5900
Article type
Paper

Synthesis and toxicity testing of cysteine-functionalized single-walled carbon nanotubes with Caenorhabditis elegans

C. M. Goodwin, G. G. Lewis, A. Fiorella, M. D. Ellison and R. Kohn, RSC Adv., 2014, 4, 5893
DOI: 10.1039/C3RA44888F

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