Issue 10, 2014

Controlled drug delivery of antileishmanial chalcones from Layer-by-Layer (LbL) self assembled PSS/PDADMAC thin films

Abstract

Layer-by-Layer (LbL) approach was applied for the encapsulation of antileishmanial drugs viz. chalcones (3-mB-4′-HC and 3-DC-4′-HC) to study their release properties at pH 7.4 from a polyelectrolyte self assembled multilayer thin film. The LbL self assembly was achieved by alternate adsorption of oppositely charged polyelectrolytes, poly(styrene-4-sulfonic acid) sodium salt (PSS) and poly(diallyldimethylammonium) chloride (PDADMAC) on planar quartz substrate. The growth of the multilayer self assembly as well as loading and release of the drugs were studied by UV-Visible spectroscopy. Both the chalcones, 3-mB-4′-HC and 3-DC-4′-HC have shown controlled and sustained release up to 224 and 824 minutes respectively. Kinetic fitting of the data confirmed that the process of drug release from the self assembly followed pseudo second order kinetics (R2 ≥ 0.99).

Graphical abstract: Controlled drug delivery of antileishmanial chalcones from Layer-by-Layer (LbL) self assembled PSS/PDADMAC thin films

Supplementary files

Article information

Article type
Paper
Submitted
23 Aug 2013
Accepted
23 Oct 2013
First published
24 Oct 2013

RSC Adv., 2014,4, 4970-4977

Controlled drug delivery of antileishmanial chalcones from Layer-by-Layer (LbL) self assembled PSS/PDADMAC thin films

U. M. Bhalerao, J. Acharya, A. K. Halve and M. P. Kaushik, RSC Adv., 2014, 4, 4970 DOI: 10.1039/C3RA44611E

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