Issue 22, 2014
From the journal:

RSC Advances

An operationally simple, palladium catalysed dehydrogenative cross-coupling reaction of pyridine N-oxides and thiazoles “on water”†

Nicky J. Willisa  and  James M. Smith*b  

* Corresponding authors

a School of Biological and Chemical Science, Queen Mary University of London, Mile End Road, London, UK
E-mail: n.j.willis@qmul.ac.uk
Fax: +44 (0)20-7882-7427
Tel: +44 (0)20-7882-3271

b Cancer Research Technology Ltd., Discovery Laboratories, Jonas Webb Building, Babraham Research Campus, Cambridge, UK
E-mail: jsmith@cancertechnology.com
Tel: +44 (0)12-2349-4008

Abstract

Herein we describe the first reported example of dehydrogenative cross-coupling of heteroaromatic moieties achieved “on water”. This reaction is catalytic in palladium, site selective and operationally simple.

Graphical abstract: An operationally simple, palladium catalysed dehydrogenative cross-coupling reaction of pyridine N-oxides and thiazoles “on water”

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Article information

DOI
https://doi.org/10.1039/C3RA44411B
Article type
Communication
Submitted
15 Aug 2013
Accepted
05 Feb 2014
First published
12 Feb 2014

RSC Adv., 2014,4, 11059-11063

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An operationally simple, palladium catalysed dehydrogenative cross-coupling reaction of pyridine N-oxides and thiazoles “on water”

N. J. Willis and J. M. Smith, RSC Adv., 2014, 4, 11059 DOI: 10.1039/C3RA44411B

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