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Issue 5, 2014
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Synthesis of 1-substituted epibatidine analogues and their in vitro and in vivo evaluation as α4β2 nicotinic acetylcholine receptor ligands

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Abstract

The highly potent natural alkaloid epibatidine remains a source of inspiration in the search for new analgesic drugs. In this paper, we describe an expansion of our previously reported synthesis of epibatidine analogues, and five synthetic alkaloids characterized by a symmetric, 1-substituted 7-azabicyclo[2.2.1]heptane skeleton, were evaluated for their biological activity. Two of these are binding selectively to the α4β2 subtype of the nicotinic acetylcholine receptor. Their Ki values were determined to be 40 and 290 nM. After a favourable evaluation of these compounds' cytotoxicity and metabolic stability, they were submitted to a rat tail flick test. The compounds did not show antinociceptive effects, which may be caused by a combination of insufficient potency and poor brain penetration.

Graphical abstract: Synthesis of 1-substituted epibatidine analogues and their in vitro and in vivo evaluation as α4β2 nicotinic acetylcholine receptor ligands

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Article information


Submitted
14 Aug 2013
Accepted
14 Nov 2013
First published
14 Nov 2013

RSC Adv., 2014,4, 2226-2234
Article type
Paper

Synthesis of 1-substituted epibatidine analogues and their in vitro and in vivo evaluation as α4β2 nicotinic acetylcholine receptor ligands

T. S. A. Heugebaert, M. Van Overtveldt, A. De Blieck, B. Wuyts, P. Augustijns, E. Ponce-Gámez, A. Rivera, D. De Groote, R. A. Lefebvre, P. Wouters, T. Meert, J. Devulder and C. V. Stevens, RSC Adv., 2014, 4, 2226
DOI: 10.1039/C3RA44379E

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