Issue 5, 2014
From the journal:

RSC Advances

Organocatalytic asymmetric biomimetic transamination of α-keto acetals to chiral α-amino acetals†

Hongjie Pan,a   Ying Xie,a   Mao Liua  and  Yian Shi*ab  

* Corresponding authors

a Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

b Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
E-mail: yian@lamar.colostate.edu
Fax: +1-970-4911801
Tel: +1-970-4917424

Abstract

This paper describes a chiral base-catalyzed asymmetric biomimetic transamination of α-keto acetals. A wide variety of α-amino acetals containing various functional groups can be synthesized in 50–85% yield and 82–86% ee.

Graphical abstract: Organocatalytic asymmetric biomimetic transamination of α-keto acetals to chiral α-amino acetals

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Article information

DOI
https://doi.org/10.1039/C3RA42906G
Article type
Communication
Submitted
12 Jun 2013
Accepted
07 Nov 2013
First published
08 Nov 2013

RSC Adv., 2014,4, 2389-2392

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Organocatalytic asymmetric biomimetic transamination of α-keto acetals to chiral α-amino acetals

H. Pan, Y. Xie, M. Liu and Y. Shi, RSC Adv., 2014, 4, 2389 DOI: 10.1039/C3RA42906G

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