Palladacycle-catalyzed cascade reaction of bicyclic alkenes with alkynyl imines: synthesis of polycyclic 5H-benzo[b]azepines

Abstract

A new methodology to prepare the unique six–seven membered [4,5,0] heterocyclic ring system, an important structure in natural products and medicinal chemistry, has been developed via a palladacycle-catalyzed cascade reaction of bicyclic alkenes and alkynyl imines. The unique catalytic activity of palladacycles as well as C–H activation under palladacycle catalysis, a new catalytic pattern of palladacycles, has been revealed.