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Issue 4, 2014
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The redox-A3 reaction

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Abstract

This highlight details the recent emergence of a new type of A3 reaction (three-component condensation of an amine, an aldehyde and an alkyne). In contrast to the classic A3 coupling process, the redox-A3 reaction incorporates an iminium isomerization step and leads to amine α-alkynylation. The overall transformation is redox-neutral by virtue of a combined reductive N-alkylation/oxidative C–H bond functionalization.

Graphical abstract: The redox-A3 reaction

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Publication details

The article was received on 21 Jan 2014, accepted on 12 Mar 2014 and first published on 13 Mar 2014


Article type: Highlight
DOI: 10.1039/C4QO00022F
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Citation: Org. Chem. Front., 2014,1, 426-429
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    The redox-A3 reaction

    D. Seidel, Org. Chem. Front., 2014, 1, 426
    DOI: 10.1039/C4QO00022F

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