Janus nanoparticles with both faces selectively functionalized for click chemistry†
Janus nanoparticles presenting one face functionalized with azide and one face functionalized with alkyne groups were prepared in water. The surface density of the functional groups could be adjusted by controlling the functional group density in the polymers used to generate the Janus particles. The control was achieved by the preparation of copolymers in which the ratio of the functional monomer was varied by free-radical polymerization and by the use of atom transfer radical polymerization (ATRP) with functional initiators. Furthermore, reagents and methods were developed to quantify the alkyne and azide groups on the surface of the Janus particles. Thus, the activity of the groups was also proven.