Rapid, semi-automated convergent synthesis of low generation triazine dendrimers using microwave assisted reactions

Abstract

Microwave assisted synthesis allows for the rapid access of low generation triazine dendrimers in high yields. Products include a macromonomer and alkyne functionalized dendrimers from generation one to three. Using a microwave assisted, convergent synthetic approach, two nucleophilic aromatic substitution reactions are executed on cyanuric chloride in 10 min at 60 °C using primary amines. Substitution of the resulting monochlorotriazine with a diamine requires 95 °C for 30 min. Purifications are accomplished using an automated chromatography system such that the generation three dendrimer can be prepared from the starting materials in less than one day.