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Issue 3, 2014
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Recent advances in glycopolypeptide synthesis

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Abstract

Glycosylated peptides and proteins are ubiquitous in nature and display a wide range of biological functions including mediation of recognition events, protection from proteases, and lubrication in eyes and joints. Similarly, synthetic glycopolypeptides are also expected to show great potential as biomedical materials (e.g. scaffolds for tissue repair and drug carriers), as well as serve as valuable tools for probing carbohydrate–protein interactions. Although block copolypeptides and other complex polypeptide architectures have been known for some time, the synthesis of complex and well-defined glycopolypeptide materials, until recently, has been challenging. This article reviews the many advances and accomplishments made in the past few years toward development of strategies and methods for the preparation of synthetic glycopolypeptides via ring opening polymerization.

Graphical abstract: Recent advances in glycopolypeptide synthesis

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Article information


Submitted
09 Aug 2013
Accepted
19 Sep 2013
First published
01 Oct 2013

Polym. Chem., 2014,5, 671-682
Article type
Review Article

Recent advances in glycopolypeptide synthesis

J. R. Kramer and T. J. Deming, Polym. Chem., 2014, 5, 671
DOI: 10.1039/C3PY01081C

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