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Issue 31, 2014
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One-pot synthesis of polysubstituted 3-acylpyrroles by cooperative catalysis

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Abstract

One-pot syntheses of polysubstituted 3-acylpyrroles from readily available unsaturated ketones and N-substituted propargylated amines have been developed. An aza-Michael/alkyne carbocyclization cascade, by cooperative catalysis using pyrrolidine and a copper salt, followed by oxidation in situ gave 3-acylpyrroles, which were also transformed further to functionalized, highly substituted 3-acylpyrroles.

Graphical abstract: One-pot synthesis of polysubstituted 3-acylpyrroles by cooperative catalysis

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The article was received on 17 May 2014, accepted on 17 Jun 2014 and first published on 17 Jun 2014


Article type: Communication
DOI: 10.1039/C4OB01019A
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Org. Biomol. Chem., 2014,12, 5822-5826

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    One-pot synthesis of polysubstituted 3-acylpyrroles by cooperative catalysis

    H. Cui and F. Tanaka, Org. Biomol. Chem., 2014, 12, 5822
    DOI: 10.1039/C4OB01019A

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