Issue 33, 2014

Multicomponent reaction of chalcones, malononitrile and DMF leading to γ-ketoamides

Abstract

An efficient synthesis of γ-ketoamides was developed by the one-pot multicomponent reaction of chalcones, malononitrile and DMF (as both the reactant and solvent) in the presence of NaOH (3.0 equiv.). The reaction features high atom economy, easily available starting materials, operational simplicity, and good tolerance with diverse functional groups.

Graphical abstract: Multicomponent reaction of chalcones, malononitrile and DMF leading to γ-ketoamides

Supplementary files

Article information

Article type
Paper
Submitted
11 May 2014
Accepted
27 Jun 2014
First published
30 Jun 2014

Org. Biomol. Chem., 2014,12, 6389-6392

Multicomponent reaction of chalcones, malononitrile and DMF leading to γ-ketoamides

E. Wei, B. Liu, S. Lin and F. Liang, Org. Biomol. Chem., 2014, 12, 6389 DOI: 10.1039/C4OB00971A

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