Issue 29, 2014
From the journal:

Organic & Biomolecular Chemistry

Synthesis of 2,3-dihydro-1H-indazoles by Rh(iii)-catalyzed C–H cleavage of arylhydrazines†

Jinzhong Yao,a   Ruokun Feng,a   Cong Lin,a   Zhanxiang Liu*a  and  Yuhong Zhang*ab  

* Corresponding authors

a Department of Chemistry, ZJU-NHU United R&D Center, Zhejiang University, Hangzhou 310027, China
E-mail: liuzhanx@zju.edu.cn, yhzhang@zju.edu.cn

b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China

Abstract

A rhodium-catalyzed efficient method for the synthesis of 2,3-dihydro-1H-indazoles is described. The reaction of arylhydrazines with olefins results in the corresponding 2,3-dihydro 1H-indazoles with exclusive regioselectivity via C–H bond activation. The utility of the methodology is illustrated by a rapid synthesis of 1H-indazoles under mild reaction conditions in half an hour.

Graphical abstract: Synthesis of 2,3-dihydro-1H-indazoles by Rh(iii)-catalyzed C–H cleavage of arylhydrazines

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C4OB00921E
Article type
Paper
Submitted
05 May 2014
Accepted
10 Jun 2014
First published
11 Jun 2014

Org. Biomol. Chem., 2014,12, 5469-5476

Permissions

Request permissions

Synthesis of 2,3-dihydro-1H-indazoles by Rh(III)-catalyzed C–H cleavage of arylhydrazines

J. Yao, R. Feng, C. Lin, Z. Liu and Y. Zhang, Org. Biomol. Chem., 2014, 12, 5469 DOI: 10.1039/C4OB00921E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements