A one-pot synthetic strategy for construction of the dibenzodiazepine skeleton via a transition metal-free process

Shuai Fang; Xiaoyi Niu; Zeyuan Zhang; Yan Sun; Xiaomeng Si; Cuicui Shan; Lei Wei; Aiqing Xu; Lei Feng; Chen Ma

doi:10.1039/C4OB00871E

A one-pot synthetic strategy for construction of the dibenzodiazepine skeleton via a transition metal-free process†

Shuai Fang,^a Xiaoyi Niu,^a Zeyuan Zhang,^a Yan Sun,^a Xiaomeng Si,^a Cuicui Shan,^a Lei Wei,^a Aiqing Xu,^a Lei Feng^a and Chen Ma*^ab

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* Corresponding authors

^a Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, P. R. China

^b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China
E-mail: chenma@sdu.edu.cn

Abstract

A one-pot transition metal-free methodology for constructing pharmacologically active dibenzodiazepine derivatives was developed. Fluoro-, bromo- and nitro-substituted aryl aldehydes were applied to this reaction efficiently.

Organic & Biomolecular Chemistry

A one-pot synthetic strategy for construction of the dibenzodiazepine skeleton via a transition metal-free process†

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A one-pot synthetic strategy for construction of the dibenzodiazepine skeleton via a transition metal-free process

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