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Issue 28, 2014
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Pyrene chromophores for the photoreversal of psoralen interstrand crosslinks

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Abstract

Applying psoralen interstrand crosslinks for the photoactivation of nucleic acids is a new concept. To find chromophores that can efficiently stimulate crosslink repair we screened several pyrenes and appended them to peptide nucleic acids for their site-selective addressing. Even though pyrenes conjugated to uracil revealed desirable spectroscopic properties they were not effective in crosslink reversal. In contrast, bare pyrenes are well suitable for crosslink repair with 350 nm light showing an uncaging efficiency similar to classical photocaging groups.

Graphical abstract: Pyrene chromophores for the photoreversal of psoralen interstrand crosslinks

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Supplementary files

Article information


Submitted
20 Mar 2014
Accepted
22 May 2014
First published
23 May 2014

This article is Open Access

Org. Biomol. Chem., 2014,12, 5260-5266
Article type
Paper

Pyrene chromophores for the photoreversal of psoralen interstrand crosslinks

J. M. Stadler and T. Stafforst, Org. Biomol. Chem., 2014, 12, 5260
DOI: 10.1039/C4OB00603H

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