Issue 30, 2014

Strategies for desymmetrising trehalose to synthesise trehalose glycolipids

Abstract

The desymmetrisation and regioselective protection of trehalose are major challenges in the chemical synthesis of biologically essential trehalose glycolipids. We reviewed the literature on desymmetrising trehalose to synthesise trehalose glycolipids and highlighted an efficient regioselective 6-O-phosphorylation method that can be applied to synthesise asymmetric trehalose glycolipids.

Graphical abstract: Strategies for desymmetrising trehalose to synthesise trehalose glycolipids

Article information

Article type
Perspective
Submitted
19 Mar 2014
Accepted
05 Jun 2014
First published
05 Jun 2014

Org. Biomol. Chem., 2014,12, 5558-5562

Author version available

Strategies for desymmetrising trehalose to synthesise trehalose glycolipids

C. Wu and C. Wang, Org. Biomol. Chem., 2014, 12, 5558 DOI: 10.1039/C4OB00587B

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