Issue 17, 2014
From the journal:

Organic & Biomolecular Chemistry

Helical folding of α/β-peptides containing β-amino acids with an eight-membered ring constraint†

Woohyung Lee,a   Sunmi Kwon,a   Philjae Kang,a   Ilia A. Guzeib  and  Soo Hyuk Choi*a  

* Corresponding authors

a Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea

b Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States

Abstract

αβα-Tripeptide that contains a cyclic β-amino acid with an eight-membered ring, a cis-2-aminocyclooct-5-enecarboxylic acid (cis-ACOE) or a cis-2-aminocyclooctanecarboxylic acid (cis-ACOC) displayed an 11/9-helical turn in the crystal state. The related α/β-peptide oligomers were shown to adopt 11/9-helical conformations in solution.

Graphical abstract: Helical folding of α/β-peptides containing β-amino acids with an eight-membered ring constraint

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Article information

DOI
https://doi.org/10.1039/C4OB00266K
Article type
Communication
Submitted
05 Feb 2014
Accepted
04 Mar 2014
First published
04 Mar 2014

Org. Biomol. Chem., 2014,12, 2641-2644

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Helical folding of α/β-peptides containing β-amino acids with an eight-membered ring constraint

W. Lee, S. Kwon, P. Kang, I. A. Guzei and S. H. Choi, Org. Biomol. Chem., 2014, 12, 2641 DOI: 10.1039/C4OB00266K

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