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Issue 19, 2014
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The development of catalytic nucleophilic substitution reactions: challenges, progress and future directions

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Abstract

Bimolecular nucleophilic substitution reactions of alcohols are fundamentally important transformations in organic chemistry yet, to date, they are relatively underdeveloped with respect to catalysis. This Article describes the emerging area of catalytic SN2 reactions with specific emphasis on the design and development of phosphorus(V) and cyclopropenone-based catalytic SN2 reactions of alcohols.

Graphical abstract: The development of catalytic nucleophilic substitution reactions: challenges, progress and future directions

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Publication details

The article was received on 06 Jan 2014, accepted on 24 Mar 2014 and first published on 25 Mar 2014


Article type: Review Article
DOI: 10.1039/C4OB00032C
Citation: Org. Biomol. Chem., 2014,12, 2993-3003

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    The development of catalytic nucleophilic substitution reactions: challenges, progress and future directions

    J. An, R. M. Denton, T. H. Lambert and E. D. Nacsa, Org. Biomol. Chem., 2014, 12, 2993
    DOI: 10.1039/C4OB00032C

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