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Issue 19, 2014
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The development of catalytic nucleophilic substitution reactions: challenges, progress and future directions

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Abstract

Bimolecular nucleophilic substitution reactions of alcohols are fundamentally important transformations in organic chemistry yet, to date, they are relatively underdeveloped with respect to catalysis. This Article describes the emerging area of catalytic SN2 reactions with specific emphasis on the design and development of phosphorus(V) and cyclopropenone-based catalytic SN2 reactions of alcohols.

Graphical abstract: The development of catalytic nucleophilic substitution reactions: challenges, progress and future directions

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Article information


Submitted
06 Jan 2014
Accepted
24 Mar 2014
First published
25 Mar 2014

Org. Biomol. Chem., 2014,12, 2993-3003
Article type
Review Article

The development of catalytic nucleophilic substitution reactions: challenges, progress and future directions

J. An, R. M. Denton, T. H. Lambert and E. D. Nacsa, Org. Biomol. Chem., 2014, 12, 2993
DOI: 10.1039/C4OB00032C

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