Issue 11, 2014
From the journal:

Organic & Biomolecular Chemistry

Rh-catalyzed oxidative C–C bond formation and C–N bond cleavage: direct access to C2-olefinated free (NH)-indoles and pyrroles†

Satyasheel Sharma,a   Sangil Han,a   Mirim Kim,a   Neeraj Kumar Mishra,a   Jihye Park,a   Youngmi Shin,a   Jimin Ha,a   Jong Hwan Kwak,a   Young Hoon Junga  and  In Su Kim*a  

* Corresponding authors

a School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: insukim@skku.edu
Fax: +82 31 292 8800
Tel: +82 31 290 7788

Abstract

The rhodium-catalyzed oxidative C2-olefination of indoles and pyrroles containing N-arylcarboxamide directing groups with a range of alkenes and subsequent cleavage of directing groups is described. This method provides direct and efficient access to C2-functionalized free (NH)-heterocycles.

Graphical abstract: Rh-catalyzed oxidative C–C bond formation and C–N bond cleavage: direct access to C2-olefinated free (NH)-indoles and pyrroles

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Article information

DOI
https://doi.org/10.1039/C3OB42605J
Article type
Communication
Submitted
11 Dec 2013
Accepted
21 Jan 2014
First published
22 Jan 2014

Org. Biomol. Chem., 2014,12, 1703-1706

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Rh-catalyzed oxidative C–C bond formation and C–N bond cleavage: direct access to C2-olefinated free (NH)-indoles and pyrroles

S. Sharma, S. Han, M. Kim, N. K. Mishra, J. Park, Y. Shin, J. Ha, J. H. Kwak, Y. H. Jung and I. S. Kim, Org. Biomol. Chem., 2014, 12, 1703 DOI: 10.1039/C3OB42605J

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