Issue 16, 2014
From the journal:

Organic & Biomolecular Chemistry

A direct access to bioactive fused N-heterocyclic acetic acid derivatives†

Raju Adepu,a   A. Rajitha,a   Dipali Ahuja,a   Atul Kumar Sharma,a   B. Ramudu,a   Ravikumar Kapavarapu,b   Kishore V. L. Parsaa  and  Manojit Pal*a  

* Corresponding authors

a Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com
Tel: +91 40 6657 1500

b Doctoral Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal

Abstract

A Cu-catalyzed new sequence involving the Ullmann type intermolecular C–C followed by an intramolecular C–N coupling and then intramolecular aza-Michael type addition (and oxidation) in a single pot afforded various fused N-heterocyclic acetic acid derivatives as inhibitors of PDE4.

Graphical abstract: A direct access to bioactive fused N-heterocyclic acetic acid derivatives

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Article information

DOI
https://doi.org/10.1039/C3OB42535E
Article type
Communication
Submitted
19 Dec 2013
Accepted
23 Jan 2014
First published
23 Jan 2014

Org. Biomol. Chem., 2014,12, 2514-2518

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A direct access to bioactive fused N-heterocyclic acetic acid derivatives

R. Adepu, A. Rajitha, D. Ahuja, A. K. Sharma, B. Ramudu, R. Kapavarapu, K. V. L. Parsa and M. Pal, Org. Biomol. Chem., 2014, 12, 2514 DOI: 10.1039/C3OB42535E

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