Issue 8, 2014
From the journal:

Organic & Biomolecular Chemistry

Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael reaction of N-BocNHOH†

R. Noël,a   V. Gembus,a   V. Levachera  and  J.-F. Brière*a  

* Corresponding authors

a Normandie Univ, COBRA, UMR 6014 et FR 3038; Univ Rouen; INSA Rouen; CNRS, IRCOF, 1 rue Tesnière, 76821 Mont Saint Aignan Cedex, France
E-mail: jean-francois.briere@insa-rouen.fr
Fax: +33 235522464
Tel: +33 235522962

Abstract

An organocatalysed and chemoselective one-pot oxa-Michael-cyclocondensation reaction of N-BocNHOH to unsaturated α-ketoesters is reported which affords an original entry to enantioenriched 3-isoxazoline carboxylate derivatives as biorelevant heterocyclic frameworks.

Graphical abstract: Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael reaction of N-BocNHOH

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Article information

DOI
https://doi.org/10.1039/C3OB42406E
Article type
Paper
Submitted
02 Dec 2013
Accepted
02 Jan 2014
First published
13 Jan 2014

Org. Biomol. Chem., 2014,12, 1245-1249

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Organocatalysed synthesis of isoxazolines initiated by a chemoselective oxa-Michael reaction of N-BocNHOH

R. Noël, V. Gembus, V. Levacher and J.-F. Brière, Org. Biomol. Chem., 2014, 12, 1245 DOI: 10.1039/C3OB42406E

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