Issue 2, 2014
From the journal:

Organic & Biomolecular Chemistry

Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives†

James McNulty,*a   Ramesh Vemula,a   Claudia Bordón,b   Robert Yolkenb  and  Lorraine Jones-Brandob  

* Corresponding authors

a Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada L8S 4M1
E-mail: jmcnult@mcmaster.ca
Fax: (+1)-905-5222509
Tel: (+1)-905-525-9140, Ext. 27393

b Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland 21287, USA

Abstract

A one-step synthesis of 4-arylquinoline-2-carboxylates along with their antiprotozoal activity against the pathogenic parasite Toxoplasma gondii is reported. Mechanistic insights into the role of Lewis acid (silver triflate) versus Bronsted acid (triflic acid) catalysis are revealed clarifying aspects of the mechanism of the quinoline synthesis.

Graphical abstract: Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

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Article information

DOI
https://doi.org/10.1039/C3OB41539B
Article type
Communication
Submitted
26 Jul 2013
Accepted
16 Nov 2013
First published
19 Nov 2013

Org. Biomol. Chem., 2014,12, 255-260

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Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives

J. McNulty, R. Vemula, C. Bordón, R. Yolken and L. Jones-Brando, Org. Biomol. Chem., 2014, 12, 255 DOI: 10.1039/C3OB41539B

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