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Issue 9, 2014
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Mechanodelivery of nanoparticles to the cytoplasm of living cells

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Abstract

Nanotechnology has opened up the opportunity to probe, sense, and manipulate the chemical environment of biological systems with an unprecedented level of spatiotemporal control. A major obstacle to the full realization of these novel technologies is the lack of a general, robust, and simple method for the delivery of arbitrary nanostructures to the cytoplasm of intact live cells. Here, we identify a new delivery modality, based on mechanical disruption of the plasma membrane, which efficiently mediates the delivery of nanoparticles to the cytoplasm of mammalian cells. We use two distinct execution modes, two adherent cell lines, and three sizes of semiconducting nanocrystals, or quantum dots, to demonstrate its applicability and effectiveness. As the underlying mechanism is purely physical, we anticipate that such “mechanodelivery” can be generalized to other modes of execution as well as to the cytoplasmic introduction of a structurally diverse array of functional nanomaterials.

Graphical abstract: Mechanodelivery of nanoparticles to the cytoplasm of living cells

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Publication details

The article was received on 06 Dec 2013, accepted on 09 Feb 2014 and first published on 21 Feb 2014


Article type: Communication
DOI: 10.1039/C3NR06468A
Citation: Nanoscale, 2014,6, 4538-4543
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    Mechanodelivery of nanoparticles to the cytoplasm of living cells

    N. T. Emerson, C. Hsia, I. U. Rafalska-Metcalf and H. Yang, Nanoscale, 2014, 6, 4538
    DOI: 10.1039/C3NR06468A

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