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Issue 3, 2014
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The role of protein characteristics in the formation and fluorescence of Au nanoclusters

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Abstract

Protein-encapsulated gold nanoclusters have shown many advantages over other gold nanocluster systems, including green synthesis, biocompatibility, high water solubility, and the ease of further conjugation. In this article, we systematically investigated the effects of the protein size and amino acid content on the formation and fluorescent properties of gold nanoclusters using four model proteins (bovine serum albumin, lysozyme, trypsin, and pepsin). We discovered that the balance of amine and tyrosine/tryptophan containing residues was critical for the nanocluster formation. Protein templates with low cysteine contents caused blue shifts in the fluorescent emissions and difference in fluorescent lifetimes of the gold nanoclusters. Furthermore, the protein size was found to be a critical factor for the photostability and long-term stability of gold nanoclusters. The size of the protein also affected the Au nanocluster behaviour after immobilization.

Graphical abstract: The role of protein characteristics in the formation and fluorescence of Au nanoclusters

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Supplementary files

Article information


Submitted
13 Nov 2013
Accepted
27 Nov 2013
First published
29 Nov 2013

Nanoscale, 2014,6, 1515-1524
Article type
Paper
Author version available

The role of protein characteristics in the formation and fluorescence of Au nanoclusters

Y. Xu, J. Sherwood, Y. Qin, D. Crowley, M. Bonizzoni and Y. Bao, Nanoscale, 2014, 6, 1515
DOI: 10.1039/C3NR06040C

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