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Issue 1, 2014
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Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies

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Abstract

Long-circulating polymeric nanotherapeutics have garnered increasing interest in research and in the clinic owing to their ability to improve the solubility and pharmacokinetics of therapeutic cargoes. Modulation of carrier properties promises more effective drug localization at the disease sites and can lead to enhanced drug safety and efficacy. In the present review, we highlight the current development of polymeric nanotherapeutics in the clinic. In light of the importance of stealth properties in therapeutic nanoparticles, we also review the advances in stealth functionalization strategies and examine the performance of different stealth polymers in the literature. In addition, we discuss the recent development of biologically inspired “self” nanoparticles, which present a differing stealth concept from conventional approaches.

Graphical abstract: Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies

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Article information


Submitted
14 Oct 2013
Accepted
29 Oct 2013
First published
04 Nov 2013

Nanoscale, 2014,6, 65-75
Article type
Review Article

Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies

C. J. Hu, R. H. Fang, B. T. Luk and L. Zhang, Nanoscale, 2014, 6, 65
DOI: 10.1039/C3NR05444F

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