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Issue 18, 2014
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Cisplatin-tethered gold nanospheres for multimodal chemo-radiotherapy of glioblastoma

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Abstract

Glioblastoma multiforme (GBM) remains the most aggressive and challenging brain tumour to treat. We report the first successful chemo-radiotherapy on patient derived treatment resistant GBM cells using a cisplatin-tethered gold nanosphere. After intracellular uptake, the nanosphere effects DNA damage which initiates caspase-mediated apoptosis in those cells. In the presence of radiation, both gold and platinum of cisplatin, serve as high atomic number radiosensitizers leading to the emission of ionizing photoelectrons and Auger electrons. This resulted in enhanced synergy between cisplatin and radiotherapy mediated cytotoxicity, and photo/Auger electron mediated radiosensitisation leading to complete ablation of the tumour cells in an in vitro model system. This study demonstrates the potential of designed nanoparticles to target aggressive cancers in the patient derived cell lines providing a platform to move towards treatment strategies.

Graphical abstract: Cisplatin-tethered gold nanospheres for multimodal chemo-radiotherapy of glioblastoma

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Supplementary files

Article information


Submitted
02 Jul 2014
Accepted
21 Jul 2014
First published
25 Jul 2014

Nanoscale, 2014,6, 10865-10873
Article type
Paper
Author version available

Cisplatin-tethered gold nanospheres for multimodal chemo-radiotherapy of glioblastoma

S. Setua, M. Ouberai, S. G. Piccirillo, C. Watts and M. Welland, Nanoscale, 2014, 6, 10865
DOI: 10.1039/C4NR03693J

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