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Issue 17, 2014
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Tunable T1 and T2 contrast abilities of manganese-engineered iron oxide nanoparticles through size control

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Abstract

In this paper, we demonstrate the tunable T1 and T2 contrast abilities of engineered iron oxide nanoparticles with high performance for liver contrast-enhanced magnetic resonance imaging (MRI) in mice. To enhance the diagnostic accuracy of MRI, large numbers of contrast agents with T1 or T2 contrast ability have been widely explored. The comprehensive investigation of high-performance MRI contrast agents with controllable T1 and T2 contrast abilities is of high importance in the field of molecular imaging. In this study, we synthesized uniform manganese-doped iron oxide (MnIO) nanoparticles with controllable size from 5 to 12 nm and comprehensively investigated their MRI contrast abilities. We revealed that the MRI contrast effects of MnIO nanoparticles are highly size-dependent. By controlling the size of MnIO nanoparticles, we can achieve T1-dominated, T2-dominated, and T1T2 dual-mode MRI contrast agents with much higher contrast enhancement than the corresponding conventional iron oxide nanoparticles.

Graphical abstract: Tunable T1 and T2 contrast abilities of manganese-engineered iron oxide nanoparticles through size control

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Publication details

The article was received on 16 May 2014, accepted on 01 Jul 2014 and first published on 03 Jul 2014


Article type: Paper
DOI: 10.1039/C4NR02680B
Citation: Nanoscale, 2014,6, 10404-10412
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    Tunable T1 and T2 contrast abilities of manganese-engineered iron oxide nanoparticles through size control

    G. Huang, H. Li, J. Chen, Z. Zhao, L. Yang, X. Chi, Z. Chen, X. Wang and J. Gao, Nanoscale, 2014, 6, 10404
    DOI: 10.1039/C4NR02680B

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