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Issue 17, 2014
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Enhanced radiation therapy with internalized polyelectrolyte modified nanoparticles

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Abstract

A challenge of X-ray radiation therapy is that high dose X-ray under therapeutic conditions damages normal cells. This paper describes a nanoparticle-based method to enhance X-ray radiation therapy by delivering radio-sensitizing gold nanoparticles into cancer cells. The nanoparticles have been modified with cationic polyelectrolytes to allow internalization. Upon X-ray irradiation of nanoparticles, more photoelectrons and Auger electrons are generated to cause water ionization, leading to formation of free radicals that damage DNA of cancer cells. The X-ray dose required for DNA damage and cell killing is reduced by delivering gold nanoparticles inside cancer cells.

Graphical abstract: Enhanced radiation therapy with internalized polyelectrolyte modified nanoparticles

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Publication details

The article was received on 21 Mar 2014, accepted on 18 May 2014 and first published on 29 May 2014


Article type: Paper
DOI: 10.1039/C4NR01564A
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Nanoscale, 2014,6, 10095-10099

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    Enhanced radiation therapy with internalized polyelectrolyte modified nanoparticles

    P. Zhang, Y. Qiao, C. Wang, L. Ma and M. Su, Nanoscale, 2014, 6, 10095
    DOI: 10.1039/C4NR01564A

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