Issue 8, 2014
From the journal:

Nanoscale

Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor†

Hsiangkuo Yuan,‡a   Christy M. Wilson,‡b   Jun Xia,‡c   Sarah L. Doyle,‡d   Shuqin Li,b   Andrew M. Fales,a   Yang Liu,e   Ema Ozaki,d   Kelly Mulfaul,d   Gabi Hanna,f   Gregory M. Palmer,f   Lihong V. Wang,c   Gerald A. Grantb  and  Tuan Vo-Dinh*ae  

* Corresponding authors

a Department of Biomedical Engineering, Fitzpatrick Institute for Photonics, Duke University, Durham, NC 27708, USA
E-mail: tuan.vodinh@duke.edu

b Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA

c Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA

d Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin 2 and the National Children's Research Centre, Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland

e Department of Chemistry, Duke University, Durham, NC 27708, USA

f Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA

Abstract

Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.

Graphical abstract: Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

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Article information

DOI
https://doi.org/10.1039/C3NR06770J
Article type
Communication
Submitted
21 Dec 2013
Accepted
26 Feb 2014
First published
04 Mar 2014

Nanoscale, 2014,6, 4078-4082

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Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor

H. Yuan, C. M. Wilson, J. Xia, S. L. Doyle, S. Li, A. M. Fales, Y. Liu, E. Ozaki, K. Mulfaul, G. Hanna, G. M. Palmer, L. V. Wang, G. A. Grant and T. Vo-Dinh, Nanoscale, 2014, 6, 4078 DOI: 10.1039/C3NR06770J

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