Synthesis of Au–Fe3O4 heterostructured nanoparticles for in vivo computed tomography and magnetic resonance dual model imaging

Jing Zhu; Yinjie Lu; Yonggang Li; Jiang Jiang; Liang Cheng; Zhuang Liu; Liang Guo; Yue Pan; Hongwei Gu

doi:10.1039/C3NR04730J

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Synthesis of Au–Fe₃O₄ heterostructured nanoparticles for in vivo computed tomography and magnetic resonance dual model imaging†

Jing Zhu,^a Yinjie Lu,^a Yonggang Li,^b Jiang Jiang,^c Liang Cheng,^d Zhuang Liu,^d Liang Guo,^b Yue Pan*^a and Hongwei Gu*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China
E-mail: hongwei@suda.edu.cn, panyue@suda.edu.cn
Fax: +86-65880905
Tel: +86-65880905

^b Department of Radiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China

^c i-Lab and Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, China

^d Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China

Abstract

Water-soluble Au–Fe₃O₄ heterostructured nanoparticles with high biocompatibility were synthesized and applied as a dual modality contrast agent. These nanoparticles present strong CT/MRI contrast enhancement in a rabbit model. Low concentrations of Au–Fe₃O₄ were found to obtain a similar effect to high concentrations of a commercial iodine agent in the CT image.

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Article information

DOI: https://doi.org/10.1039/C3NR04730J
Article type: Communication
Submitted: 04 Sep 2013
Accepted: 22 Oct 2013
First published: 25 Oct 2013

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Nanoscale, 2014,6, 199-202

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Synthesis of Au–Fe₃O₄ heterostructured nanoparticles for in vivo computed tomography and magnetic resonance dual model imaging

J. Zhu, Y. Lu, Y. Li, J. Jiang, L. Cheng, Z. Liu, L. Guo, Y. Pan and H. Gu, Nanoscale, 2014, 6, 199 DOI: 10.1039/C3NR04730J

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