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Issue 11, 2014
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The anti-inflammatory properties of Au–scopoletin nanoconjugates

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Abstract

We investigated the biological activity of Au nanoparticles with a mean diameter of 30 nm which were capped with scopoletin, a natural coumarin isolated from Artemisia roxburghiana along with eleven other natural products. The NO inhibitory activity of scopoletin was unaffected by conjugation to the Au nanoparticles. A luminol chemiluminescence assay showed instead that conjugation increased the prevention of an oxidative burst of reactive oxygen species (ROS) in whole blood phagocytes and isolated neutrophils (PMN) by about three times.

Graphical abstract: The anti-inflammatory properties of Au–scopoletin nanoconjugates

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Article information


Submitted
15 May 2014
Accepted
08 Sep 2014
First published
09 Sep 2014

New J. Chem., 2014,38, 5566-5572
Article type
Paper
Author version available

The anti-inflammatory properties of Au–scopoletin nanoconjugates

M. R. Shah, A. Shamim, L. S. White, M. F. Bertino, M. A. Mesaik and S. Soomro, New J. Chem., 2014, 38, 5566
DOI: 10.1039/C4NJ00792A

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