Aggregation behaviour of betablocker drugs in aqueous media†
Abstract
The presence of pharmaceutical chemicals in the aquatic environment is a cause of concern. Knowledge of the behaviour of these compounds in water is important to identify and comprehend the consequences of their occurrence in the environment. For a better understanding of the aqueous behaviour of some pharmaceuticals, the critical aggregation concentration (cac) of several drugs in aqueous solution has been measured at 298.15 K through density (ρ), speed of sound (u) and conductivity (κ) measurements. In addition, isentropic compressibilities (κs) have been calculated from the experimental data. Moreover, solubilities have been obtained at the same temperature and the partition coefficients have been calculated theoretically using the ALOGPS method.