Aggregation behaviour of betablocker drugs in aqueous media

Abstract

The presence of pharmaceutical chemicals in the aquatic environment is a cause of concern. Knowledge of the behaviour of these compounds in water is important to identify and comprehend the consequences of their occurrence in the environment. For a better understanding of the aqueous behaviour of some pharmaceuticals, the critical aggregation concentration (cac) of several drugs in aqueous solution has been measured at 298.15 K through density (ρ), speed of sound (u) and conductivity (κ) measurements. In addition, isentropic compressibilities (κ_s) have been calculated from the experimental data. Moreover, solubilities have been obtained at the same temperature and the partition coefficients have been calculated theoretically using the ALOGPS method.