Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 6, 2014
Previous Article Next Article

Specific antitumor activities of natural and oxovanadium(iv) complexed flavonoids in human breast cancer cells

Author affiliations

Abstract

The structure–activity relationships of the natural flavonoids quercetin, chrysin and silibinin have revealed that they meet the key structural requirements for killing tumor cells. When the structures of these three flavonoids are modified by complexation using the oxovanadium(IV) cation their cytotoxic properties in human breast cancer cell lines are enhanced. Breast epithelial cells are used to determine the selectivity of these compounds. The mechanisms of action of the flavonoids and the oxovanadium(IV) cation in the MDA-MB231 cell line seem to be different to the apoptotic mechanisms of cell death exerted by the oxovanadium(IV) complexes. These results showed the mechanisms of the antitumoral effect of these complexes, making them promising compounds for cancer treatment.

Graphical abstract: Specific antitumor activities of natural and oxovanadium(iv) complexed flavonoids in human breast cancer cells

Back to tab navigation

Supplementary files

Article information


Submitted
27 Dec 2013
Accepted
03 Mar 2014
First published
04 Mar 2014

New J. Chem., 2014,38, 2414-2421
Article type
Paper

Specific antitumor activities of natural and oxovanadium(IV) complexed flavonoids in human breast cancer cells

L. Naso, M. Valcarcel, P. Villacé, M. Roura-Ferrer, C. Salado, E. G. Ferrer and P. A. M. Williams, New J. Chem., 2014, 38, 2414
DOI: 10.1039/C3NJ01649H

Social activity

Search articles by author

Spotlight

Advertisements