Synthesis, spectroscopic characterization, X-ray structure and electrochemistry of new bis(1,2-diaminocyclohexane)gold(iii) chloride compounds and their anticancer activities against PC3 and SGC7901 cancer cell lines

Abstract

New gold(III) compounds with chemical formulae [Au{cis-(1,2-DACH)}₂]Cl₃1, [Au{trans-(±)-(1,2-DACH)}₂]Cl₃2 and [Au{(S,S)-(+)-1,2-(DACH)}₂]Cl₃3 (where 1,2-DACH = 1,2-diaminocyclohexane) have been synthesized. The synthesized compounds were characterized using elemental analysis, various spectroscopic techniques including UV-vis, FTIR spectroscopy, solution and solid-state NMR measurements; and X-ray crystallography. The stability of compounds 1, 2 and 3 was checked by UV-vis spectroscopy and NMR measurements. The electrochemical behavior was also investigated through cyclic voltammetry. The potential of the three compounds as anticancer agents was investigated by measuring in vitro cytotoxicity in terms of IC₅₀ and inhibitory effects on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines. [Au{trans-(±)-(1,2-DACH)}₂]Cl₃ (2) showed a better in vitro inhibitory effect on growth of human prostate (PC3) and gastric (SGC7901) cancer cell lines than [Au{cis-(1,2-DACH)}₂]Cl₃ (1) and [Au{(S,S)-(+)-(1,2-DACH)}₂]Cl₃ (3).