Nano-CoFe2O4 supported molybdenum as an efficient and magnetically recoverable catalyst for a one-pot, four-component synthesis of functionalized pyrroles

Abstract

A novel magnetic nanoparticle CoFe₂O₄ supported Mo ([CoFe₂O₄@SiO₂-PrNH₂-Mo(acac)₂]) was prepared and found to be a highly active and efficient catalyst for a one-pot synthesis of polysubstituted pyrroles via four-component reaction of aldehydes, amines, 1,3-dicarbonyl compounds and nitromethane. The easy recovery of the catalyst and reusability, broad substrate scopes, short reaction time, high yields of products and solvent-free conditions make this protocol practical, environmentally friendly and economically attractive.