Jump to main content
Jump to site search

Issue 1, 2014
Previous Article Next Article

CuInS2 quantum dots@silica near-infrared fluorescent nanoprobe for cell imaging

Author affiliations

Abstract

In this paper, near-infrared (NIR) fluorescent CuInS2 QDs@SiO2 nanobeads were prepared and used as fluorescent nanoprobes for prostate cancer cells imaging. The core–shell CuInS2 QDs@SiO2 nanobeads with controllable particle sizes were synthesized via a reverse microemulsion method. Further surface modifications were performed for grafting amino groups on the surface of the NIR CuInS2 QDs@SiO2 nanobeads. For prostate cancer cell imaging, anti-PSCA antibody was conjugated to the NIR CuInS2 QDs@SiO2 nanobeads to prepare the anti-PSCA–QDs@SiO2 nanoprobe. The specific binding of the antibody conjugated CuInS2 QDs@SiO2 nanobeads to the surface of human prostate cancer cells (PC-3M) was confirmed by fluorescence microscopy. MTT assay and fluorescence microscopy images showed that the anti-PSCA-conjugated NIR CuInS2 QDs@SiO2 nanoprobe was a non-toxic nanoprobe and had high-specificity in cell imaging. The CuInS2 QDs@SiO2 nanoprobe as an efficient NIR imaging nanoprobe could be used for target imaging, biological assays and early diagnosis of cancer.

Graphical abstract: CuInS2 quantum dots@silica near-infrared fluorescent nanoprobe for cell imaging

Back to tab navigation

Publication details

The article was received on 16 Aug 2013, accepted on 10 Sep 2013 and first published on 11 Sep 2013


Article type: Paper
DOI: 10.1039/C3NJ00957B
Citation: New J. Chem., 2014,38, 90-96
  •   Request permissions

    CuInS2 quantum dots@silica near-infrared fluorescent nanoprobe for cell imaging

    Z. Lin, X. Fei, Q. Ma, X. Gao and X. Su, New J. Chem., 2014, 38, 90
    DOI: 10.1039/C3NJ00957B

Search articles by author

Spotlight

Advertisements