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Issue 12, 2014
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Effects of vanadium (V) and magnesium (Mg) on rat bone tissue: mineral status and micromorphology. Consequences of V–Mg interactions

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Abstract

The extent to which the 12 week separate and combined administration of vanadium (as sodium metavanadate – SMV, 0.125 mg V per ml) and magnesium (as magnesium sulphate – MS, 0.06 mg Mg per ml) affects bone mineral status and micromorphology as well as the alkaline phosphatase (ALP) activity in femoral diaphysis (FD) was examined in male rats. The bone chemical composition of SMV-exposed rats was also investigated. SMV alone or in combination with MS (as SMV–MS) reduced the levels of MgFD (by 21% and 20%) and PFD (by 12% and 9%), lowered the CaFD content (by 7% and 10%), and caused a rise of the FeFD concentration (by 22.5% and 17%), compared with the control; SMV alone also reduced and enhanced the KFD and ZnFD concentrations (by 19% and 15%, respectively) but remained without significant effect on the femoral bone surface roughness (FBSR), whereas MS alone lowered the VFD, PFD, and CuFD levels (by 42%, 10%, and 20.6%), reduced FBSR, and created the regular femoral bone surface shape. The SMV–MS combination also induced a decline and rise in the levels of CuFD (by 30%) and NaFD (by 15%), respectively, compared with the control and the MS-supplemented rats; elevated ALPFD activity (by 24%, 35%, and 40%), compared with the control, SMV-exposed, and MS-supplemented animals; and increased FBSR. Relationships between the root mean square roughness (Sq) and skewness (Ssk): Sq [MS < SMV < Control < SMV–MS] ⇔ Ssk [SMV–MS > Control > SMV > MS], ALPFD and Sq: ALPFD ⇔ Sq [SMV–MS > Control > SMV > MS], and between other variables were demonstrated. A partial limitation of the drop in the PFD and KFD levels and normalization of the ZnFD concentration were a consequence of the V–Mg antagonistic interaction whereas a consequence of the V–Mg synergistic interaction was the increase in the NaFD level, ALPFD activity, and FBSR. Ca10(PO4)5(SiO4)(OH) was part of the inorganic component of the bone of the SMV-exposed rats.

Graphical abstract: Effects of vanadium (V) and magnesium (Mg) on rat bone tissue: mineral status and micromorphology. Consequences of V–Mg interactions

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Publication details

The article was received on 07 Sep 2014, accepted on 27 Oct 2014 and first published on 28 Oct 2014


Article type: Paper
DOI: 10.1039/C4MT00234B
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Citation: Metallomics, 2014,6, 2260-2278

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    Effects of vanadium (V) and magnesium (Mg) on rat bone tissue: mineral status and micromorphology. Consequences of V–Mg interactions

    A. Ścibior, A. Adamczyk, R. Mroczka, I. Niedźwiecka, D. Gołębiowska and E. Fornal, Metallomics, 2014, 6, 2260
    DOI: 10.1039/C4MT00234B

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