Jump to main content
Jump to site search

Issue 8, 2014
Previous Article Next Article

Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

Author affiliations

Abstract

The unique properties of transition metal complexes, such as environment-responsive ligand exchange kinetics, diverse photochemical and photophysical properties, and the ability to form specific interactions with biomolecules, make them interesting platforms for selective drug delivery. This minireview will focus on recent examples of rationally designed complexes with bioactive ligands, exploring the different roles of the metal, and mechanisms of ligand release. Developments in the techniques used to study the mechanisms of action of metal–drug complexes will also be discussed, including X-ray protein crystallography, fluorescence lifetime imaging, and X-ray absorption spectroscopy.

Graphical abstract: Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

Back to tab navigation

Article information


Submitted
07 Mar 2014
Accepted
14 May 2014
First published
14 May 2014

This article is Open Access

Metallomics, 2014,6, 1324-1335
Article type
Minireview
Author version available

Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

A. K. Renfrew, Metallomics, 2014, 6, 1324
DOI: 10.1039/C4MT00069B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements