Issue 9, 2014
From the journal:

MedChemComm

Gold(i) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro†

M. Serratice,‡a   B. Bertrand,‡bc   E. F. J. Janssen,b   E. Hemelt,b   A. Zucca,a   F. Cocco,a   M. A. Cinellu*a  and  A. Casini*b  

* Corresponding authors

a Università degli Studi di Sassari, Dipartimento di Chimica e Farmacia, Via Vienna, 2, Sassari, Italy
E-mail: cinellu@uniss.it
Fax: +39 079 229559

b Dept. of Pharmacokinetics, Toxicology and Targeting, Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
E-mail: a.casini@rug.nl
Fax: +31 50 363 3274

c Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302 CNRS Université de Bourgogne, Dijon, France

Abstract

A number of gold(I) complexes containing the proton pump inhibitor (PPI) lansoprazole and its reduced precursor 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylthio)-1H-benzo[d]imidazole have been synthesized and their biological effects have been evaluated in human cancer and non-tumorigenic cells in vitro. The lansoprazole-based compounds appear to act through a V-H+-ATPase-mediated mechanism.

Graphical abstract: Gold(i) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro

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Article information

DOI
https://doi.org/10.1039/C4MD00241E
Article type
Concise Article
Submitted
06 Jun 2014
Accepted
21 Jul 2014
First published
21 Jul 2014

Med. Chem. Commun., 2014,5, 1418-1422

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Gold(I) compounds with lansoprazole-type ligands: synthesis, characterization and anticancer properties in vitro

M. Serratice, B. Bertrand, E. F. J. Janssen, E. Hemelt, A. Zucca, F. Cocco, M. A. Cinellu and A. Casini, Med. Chem. Commun., 2014, 5, 1418 DOI: 10.1039/C4MD00241E

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