Issue 8, 2014

New trends in the use of aminoglycosides

Abstract

Despite their inherent toxicity and the acquired bacterial resistance that continuously threaten their long-term clinical use, aminoglycosides (AGs) still remain valuable components of the antibiotic armamentarium. Recent literature shows that the AGs' role has been further expanded as multi-tasking players in different areas of study. This review aims at presenting some of the new trends observed in the use of AGs in the past decade, along with the current understanding of their mechanisms of action in various bacterial and eukaryotic cellular processes.

Graphical abstract: New trends in the use of aminoglycosides

Article information

Article type
Review Article
Submitted
08 Apr 2014
Accepted
13 May 2014
First published
15 May 2014

Med. Chem. Commun., 2014,5, 1075-1091

New trends in the use of aminoglycosides

M. Y. Fosso, Y. Li and S. Garneau-Tsodikova, Med. Chem. Commun., 2014, 5, 1075 DOI: 10.1039/C4MD00163J

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