Thiazole-based aminopyrimidines and N-phenylpyrazolines as potent antimicrobial agents: synthesis and biological evaluation

Abstract

A series of eight thiazole-based N-phenylpyrazolines and two aminopyrimidines having several chalcone derivatives as precursors have been synthesized and evaluated for their antimicrobial activity. All compounds showed antimicrobial activity. The best activity was achieved for compounds 3a and 3b, while compounds 4d and 4g showed the lowest antimicrobial potential.