Issue 5, 2014
From the journal:

MedChemComm

Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity evaluation and mode of action study†

Anuj Thakur,a   Sunny Manohar,a   Christian E. Vélez Gerena,b   Beatriz Zayas,b   Vineet Kumar,c   Sanjay V. Malhotra*c  and  Diwan S. Rawat*a  

* Corresponding authors

a Department of Chemistry, University of Delhi, Delhi-110007, India
E-mail: dsrawat@chemistry.du.ac.in
Fax: +91-11-27667501
Tel: +91-11-27662683

b School of Environmental Affairs, Universidad Metropolitana, San Juan, Puerto Rico, USA

c Laboratory of Synthetic Chemistry, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
E-mail: malhotrasa@mail.nih.gov
Tel: +1-301-846-5141

Abstract

A series of eighteen novel 3,5-bis(arylidiene)-4-piperidone based symmetrical monocarbonyl analogs of curcumin were synthesised and a subset was screened by National Cancer Institute (NCI), USA for their anticancer activity. Dose–response studies and the mechanism of action investigation suggest that most active compounds are apoptosis inducers.

Graphical abstract: Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity evaluation and mode of action study

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Article information

DOI
https://doi.org/10.1039/C3MD00399J
Article type
Concise Article
Submitted
31 Dec 2013
Accepted
07 Feb 2014
First published
11 Feb 2014

Med. Chem. Commun., 2014,5, 576-586

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Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: anticancer activity evaluation and mode of action study

A. Thakur, S. Manohar, C. E. Vélez Gerena, B. Zayas, V. Kumar, S. V. Malhotra and D. S. Rawat, Med. Chem. Commun., 2014, 5, 576 DOI: 10.1039/C3MD00399J

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