Issue 4, 2014

Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging

Abstract

The synthesis of fluorine-18 labeled 3-fluoro-5-[(pyridin-3-yl)ethynyl] benzonitrile ([18F]FPEB) for imaging metabotropic glutamate receptor subtype type 5 (mGluR5) was achieved with a commercial continuous-flow microfluidics device. This work represents the first positron emission tomography (PET) radiopharmaceutical that is suitable for human use with this technology. We also describe a validated synthesis of [18F]FPEB with a commercial reactor-based system.

Graphical abstract: Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging

Supplementary files

Article information

Article type
Concise Article
Submitted
31 Oct 2013
Accepted
03 Dec 2013
First published
11 Dec 2013

Med. Chem. Commun., 2014,5, 432-435

Microfluidic continuous-flow radiosynthesis of [18F]FPEB suitable for human PET imaging

S. H. Liang, D. L. Yokell, R. N. Jackson, P. A. Rice, R. Callahan, K. A. Johnson, D. Alagille, G. Tamagnan, T. Lee Collier and N. Vasdev, Med. Chem. Commun., 2014, 5, 432 DOI: 10.1039/C3MD00335C

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