Synthesis of metergoline analogues and their evaluation as antiplasmodial agents

Abstract

A series of compounds based on metergoline were synthesized and evaluated in vitro for their antiplasmodial activity against the chloroquine-sensitive NF54 strain of the malaria parasite Plasmodium falciparum. These compounds were also screened for their cytotoxicity towards a mammalian cell line. Some of the compounds exhibited superior antiplasmodial activity with a good selectivity index relative to metergoline.