Issue 3, 2014
From the journal:

Molecular BioSystems

Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation†

Andrew Millard,a   David J. Scanlan,*b   Connor Gallagher,c   Andrew Marshc  and  Paul C. Taylor*c  

* Corresponding authors

a Division of Microbiology and Infection, Warwick Medical School, University of Warwick, Coventry, UK

b School of Life Sciences, University of Warwick, Coventry, UK

c Department of Chemistry, University of Warwick, Coventry, UK
E-mail: p.c.taylor@warwick.ac.uk
Fax: +44 (0)24 76524112
Tel: +44 (0)24 76524375

Abstract

Biosynthesis of retinoic acid from retinaldehyde (retinal) is catalysed by an aldehyde dehydrogenase (ALDH) and its oxidation by cytochrome P450 enzymes (CYPs). Herein we show by phylogenetic analysis that the ALDHs and CYPs in the retinoic acid pathway in animals are much closer in evolutionary terms to cyanobacterial orthologs than would be expected from the standard models of evolution.

Graphical abstract: Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation

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Article information

DOI
https://doi.org/10.1039/C3MB70447E
Article type
Communication
Submitted
04 Oct 2013
Accepted
03 Jan 2014
First published
06 Jan 2014

Mol. BioSyst., 2014,10, 380-383

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Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation

A. Millard, D. J. Scanlan, C. Gallagher, A. Marsh and P. C. Taylor, Mol. BioSyst., 2014, 10, 380 DOI: 10.1039/C3MB70447E

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