Issue 11, 2014

Recent advances in the structure-based rational design of TNKSIs

Abstract

Human tankyrases 1 and 2 (TNKS1/2) are attractive pharmacological biotargets, especially for the treatment of specific types of cancer. This article provides a fairly comprehensive overview of the structural biology of the TNKS–inhibitor complex and the current medicinal chemistry strategies being used in the structure-based rational design of tankyrase-specific inhibitors.

Graphical abstract: Recent advances in the structure-based rational design of TNKSIs

Article information

Article type
Review Article
Submitted
30 Jun 2014
Accepted
26 Aug 2014
First published
28 Aug 2014

Mol. BioSyst., 2014,10, 2783-2799

Author version available

Recent advances in the structure-based rational design of TNKSIs

P. Zhan, Y. Song, Y. Itoh, T. Suzuki and X. Liu, Mol. BioSyst., 2014, 10, 2783 DOI: 10.1039/C4MB00385C

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