Issue 1, 2014

Complementarity between distance- and probability-based methods of gene neighbourhood identification for pathway reconstruction

Abstract

Identifying gene neighbourhoods using either distance- or probability-based measures has proven effective in retrieving co-functional links. We report that these two approaches are highly complementary, with differential sensitivity for the core pathway links. We demonstrate that integrating these measures improves prediction of both pathways and phenotypes.

Graphical abstract: Complementarity between distance- and probability-based methods of gene neighbourhood identification for pathway reconstruction

Article information

Article type
Communication
Submitted
26 Aug 2013
Accepted
21 Oct 2013
First published
23 Oct 2013

Mol. BioSyst., 2014,10, 24-29

Complementarity between distance- and probability-based methods of gene neighbourhood identification for pathway reconstruction

J. Shin, T. Lee, H. Kim and I. Lee, Mol. BioSyst., 2014, 10, 24 DOI: 10.1039/C3MB70366E

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