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Issue 14, 2014
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Magnetic sensing technology for molecular analyses

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Magnetic biosensors, based on nanomaterials and miniature electronics, have emerged as a powerful diagnostic platform. Benefiting from the inherently negligible magnetic background of biological objects, magnetic detection is highly selective even in complex biological media. The sensing thus requires minimal sample purification and yet achieves a high signal-to-background contrast. Moreover, magnetic sensors are also well-suited for miniaturization to match the size of biological targets, which enables sensitive detection of rare cells and small amounts of molecular markers. We herein summarize recent advances in magnetic sensing technologies, with an emphasis on clinical applications in point-of-care settings. Key components of sensors, including magnetic nanomaterials, labeling strategies and magnetometry, are reviewed.

Graphical abstract: Magnetic sensing technology for molecular analyses

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The article was received on 12 Mar 2014, accepted on 12 May 2014 and first published on 02 Jun 2014

Article type: Critical Review
DOI: 10.1039/C4LC00314D
Citation: Lab Chip, 2014,14, 2385-2397
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    Magnetic sensing technology for molecular analyses

    D. Issadore, Y. I. Park, H. Shao, C. Min, K. Lee, M. Liong, R. Weissleder and H. Lee, Lab Chip, 2014, 14, 2385
    DOI: 10.1039/C4LC00314D

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